Vichy LiftActiv Pure Retinol Serum — Efficacy 4.1/5.0, Safety 4.1/5.0 | DemythSkin
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[ DemythSkin Verdict ]
Vichy LiftActiv Pure Retinol Serum

Vichy LiftActiv Pure Retinol Serum

SerumDeep wrinkles and anti-aging
Efficacy
Strong
4.1 / 5.0
Safety
Mostly Safe
4.1 / 5.0
System Verdict
Solid mid-tier retinol serum with clinical backing, but alcohol denat. and low 0.2% concentration prevent elite status. Efficacy score of 4.1 reflects 0.2% pure retinol (effective per 5-month study showing wrinkle reduction in 100% of participants) paired synergistically with Matrixyl peptides and barrier-supporting Vitreoscilla ferment, but deducts for mid-range concentration (optimal clinical retinol often 0.3-1%), alcohol denat. as solvent risking irritation/dryness, and lack of encapsulation for stability; no pH issues noted but Tocopherol presence aids mild synergy without ferulic acid boost.[1][2][3]
Active Ingredients Detected
S Tier: Gold StandardsHigh Clinical Proof | Skin-Transformative
Retinol
A Tier: Good BasicsProven Results
Vitreoscilla FermentSodium HyaluronateGlycerinTocopherol
B Tier: Supporting IngredientsPromising Ingredients
Palmitoyl Tetrapeptide-7Palmitoyl Tripeptide-1
D Tier: Potential IrritantsBe Cautious
Alcohol Denat.
What Each Ingredient Does
Retinol
0.2% pure anti-aging active
Palmitoyl Tetrapeptide-7
Reduces inflammation peptides
Palmitoyl Tripeptide-1
Stimulates collagen production
Vitreoscilla Ferment
Barrier repair prebiotic
Sodium Hyaluronate
Hydrates skin surface
Glycerin
Humectant moisturizer
Alcohol Denat.
Solvent potential irritant
Tocopherol
Vitamin E antioxidant
Full Ingredient List (INCI)

Aqua / Water / Eau, Glycerin, Pentylene Glycol, Isononyl Isononanoate, Alcohol Denat., Dicaprylyl Ether, Glycine Soja Oil / Soybean Oil, Propylene Glycol, Peg-6 Caprylic/Capric Glycerides, Hydrolyzed Rice Protein, Hydroxyacetophenone, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Vitreoscilla Ferment, Retinol, Dicaprylyl Carbonate, Ammonium Polyacryloyldimethyl Taurate, Butylene Glycol, Caprylyl Glycol, Carbomer, Glyceryl Isostearate, Polysorbate 20, Ppg-6-Decyltetradeceth-30, Sodium Lactate, Tocopherol, Xanthan Gum (F.I.L. N290078/1).[1][2]

Frequently Asked

Is Vichy LiftActiv Pure Retinol Serum worth it?

Vichy LiftActiv Pure Retinol Serum scores 4.1 out of 5.0 for efficacy (Strong) and 4.1 out of 5.0 for safety (Mostly Safe) on DemythSkin's independent ingredient analysis. Solid mid-tier retinol serum with clinical backing, but alcohol denat. and low 0.2% concentration prevent elite status. Efficacy score of 4.1 reflects 0.2% pure retinol (effective per 5-month study showing wrinkle reduct

What are the key active ingredients in Vichy LiftActiv Pure Retinol Serum?

Vichy LiftActiv Pure Retinol Serum contains these gold-standard actives with strong clinical evidence: Retinol.

Does Vichy LiftActiv Pure Retinol Serum contain fragrance or known irritants?

DemythSkin flags these ingredients in Vichy LiftActiv Pure Retinol Serum as potential irritants: Alcohol Denat..

How is Vichy LiftActiv Pure Retinol Serum scored?

DemythSkin grades every product on two independent axes: efficacy (whether the ingredients have clinical evidence of working) and safety (irritation and sensitisation risk). Ingredients are classified S through D against a database of over 3,000 compounds. No brand pays for a score.

Analyze on DemythSkin →

Analysis last updated: 2026-04-22. DemythSkin is an independent ingredient analyzer. Scores are computed by a deterministic rubric from published clinical evidence — no brand pays for a score.