The Ordinary Multi-Peptide + HA Serum — Efficacy 4.1/5.0, Safety 4.5/5.0 | DemythSkin
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[ DemythSkin Verdict ]
The Ordinary Multi-Peptide + HA Serum
The Ordinary

The Ordinary Multi-Peptide + HA Serum

SerumAnti-Aging
Efficacy
Strong
4.1 / 5.0
Safety
Safe
4.5 / 5.0
System Verdict
This is a high-efficacy peptide hydrator that actually earns its anti-aging claims, but it’s still a sophisticated humectant serum—not a miracle Botox-in-a-bottle. Multiple S Tier peptides (Matrixyl 3000, Matrixyl synthe’6, Syn-Ake, Argirelox) are clustered high in the INCI and supported by a dense humectant/amino-acid base, giving real long-term anti-aging and hydration benefits, but the mechanism is slow, subtle and entirely dependent on consistent twice-daily use rather than dramatic short-term tightening.
Active Ingredients Detected
A Tier: Good BasicsProven Results
GlycerinLactococcus Ferment LysateAcetylarginyltryptophyl DiphenylglycineSodium Hyaluronate CrosspolymerSodium HyaluronateAllantoinGlycineAlanineSerineValineIsoleucineProlineThreonineHistidinePhenylalanineTrehaloseUreaSodium PCA
B Tier: Supporting IngredientsPromising Ingredients
Acetyl Hexapeptide-8Pentapeptide-18Palmitoyl Tripeptide-1Palmitoyl Tetrapeptide-7Palmitoyl Tripeptide-38Dipeptide Diaminobutyroyl Benzylamide DiacetateAspartic AcidFructoseGlucoseMaltosePCAHydroxypropyl CyclodextrinSodium ChlorideAcacia Senegal GumPPG-26-Buteth-26PEG-40 Hydrogenated Castor OilTrisodium Ethylenediamine DisuccinateEthoxydiglycol
What Each Ingredient Does
Aqua (Water)
Solvent base
Glycerin
Humectant for hydration
Lactococcus Ferment Lysate
Skin-conditioning postbiotic
Acetyl Hexapeptide-8
Peptide for expression lines
Pentapeptide-18
Peptide targeting wrinkles
Palmitoyl Tripeptide-1
Matrixyl 3000 collagen peptide
Palmitoyl Tetrapeptide-7
Matrixyl 3000 anti-inflammatory peptide
Palmitoyl Tripeptide-38
Matrixyl synthe’6 collagen peptide
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Syn-Ake peptide for fine lines
Acetylarginyltryptophyl Diphenylglycine
Argirelox peptide for dynamic wrinkles
Sodium Hyaluronate Crosspolymer
Crosslinked hyaluronic acid humectant
Sodium Hyaluronate
Hyaluronic acid humectant
Allantoin
Soothing and skin-protective
Glycine
Amino acid, skin-identical
Alanine
Amino acid humectant
Serine
Amino acid humectant
Valine
Amino acid, skin-conditioning
Isoleucine
Amino acid, skin-conditioning
Proline
Amino acid, humectant
Threonine
Amino acid, skin-conditioning
Histidine
Amino acid, humectant
Phenylalanine
Amino acid, skin-conditioning
Arginine
Amino acid, humectant
Aspartic Acid
Amino acid, humectant
Full Ingredient List (INCI)

Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

Frequently Asked

Is The Ordinary Multi-Peptide + HA Serum worth it?

The Ordinary Multi-Peptide + HA Serum scores 4.1 out of 5.0 for efficacy (Strong) and 4.5 out of 5.0 for safety (Safe) on DemythSkin's independent ingredient analysis. This is a high-efficacy peptide hydrator that actually earns its anti-aging claims, but it’s still a sophisticated humectant serum—not a miracle Botox-in-a-bottle. Multiple S Tier peptides (Matrixyl 3000, Matrixyl synthe

What are the key active ingredients in The Ordinary Multi-Peptide + HA Serum?

The Ordinary Multi-Peptide + HA Serum contains no gold-standard actives — its formula is built on supporting and base ingredients rather than clinically transformative actives.

Does The Ordinary Multi-Peptide + HA Serum contain fragrance or known irritants?

DemythSkin's analysis found no flagged irritants in The Ordinary Multi-Peptide + HA Serum. It scores 4.5 out of 5.0 for safety.

How is The Ordinary Multi-Peptide + HA Serum scored?

DemythSkin grades every product on two independent axes: efficacy (whether the ingredients have clinical evidence of working) and safety (irritation and sensitisation risk). Ingredients are classified S through D against a database of over 3,000 compounds. No brand pays for a score.

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Analysis last updated: 2026-07-13. DemythSkin is an independent ingredient analyzer. Scores are computed by a deterministic rubric from published clinical evidence — no brand pays for a score. DemythSkin earns commission from affiliate links (Amazon Associates and others). Scores are computed before any commercial relationship — the link follows the verdict, never the other way around.