All scans / Moisturizers / SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream
SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream ingredients: is it worth it?
A credible peptide moisturizer, not a topical Botox substitute.

A credible peptide moisturizer, not a topical Botox substitute.
READ MORE
Efficacy is 3.9/5 because niacinamide appears third and is supported by humectants, fatty acids, shea butter, ceramide NP, adenosine, and peptides; the formula should improve barrier function, hydration, and the appearance of fine lines. The score is held below the top tier because the headline Myrixin/plant-extract story is not independently established as a high-evidence wrinkle treatment, peptide concentrations are undisclosed and appear near the end of the list, and LHA and zinc PCA advertised in the product positioning are not present in the complete INCI transcription supplied by the retailer. Safety is 4.6/5: no denatured alcohol, fragrance, essential oils, or aggressive surfactants are listed, though botanical extracts and a rich emollient base may not suit every acne-prone user.
We may earn a commission from qualifying purchases. Links never influence scores.
DemythSkin rates SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream 3.9/5 for efficacy and 4.6/5 for safety.
ACTIVE INGREDIENTS BY TIER
Gold Standards
High clinical proof | Skin-transformativeReliable
Proven resultsPotent
Developing evidenceOverhyped | Marketing
Hype | Limited dataDocumented Irritants
Evidence-backed flagFORMULATION BASE (18)⌄
FULL INGREDIENT LIST⌄
Aqua / Water / Eau, Butylene Glycol, Niacinamide, Glycerin, Dicaprylyl Carbonate, Pentylene Glycol, Cetearyl Alcohol, 1,2-Hexanediol, Isododecane, C14-22 Alcohols, Caprylic/Capric Triglyceride, Vinyl Dimethicone, Macadamia Integrifolia Seed Oil, Glyceryl Stearate SE, C12-20 Alkyl Glucoside, Nymphaea Alba Flower Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Butyrospermum Parkii Butter / Shea Butter, C12-16 Alcohols, Tromethamine, Luffa Cylindrica Fruit/Leaf/Stem Extract, Hydrogenated Lecithin, Palmitic Acid, Cetyl Palmitate, Ethylhexylglycerin, Adenosine, Sorbitan Stearate, Polysorbate 80, Tocopherol, Ceramide NP, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Sodium Benzoate, Citric Acid, Palmitoyl Tetrapeptide-10
WHAT EACH INGREDIENT DOES (24)⌄
- Aqua / Water / Eau
- formula solvent
- Butylene Glycol
- humectant and solvent
- Niacinamide
- barrier and tone support
- Glycerin
- water-binding humectant
- Dicaprylyl Carbonate
- light emollient
- Pentylene Glycol
- humectant and solvent
- Cetearyl Alcohol
- fatty alcohol thickener
- 1,2-Hexanediol
- solvent and preservative booster
- Isododecane
- volatile emollient
- C14-22 Alcohols
- emulsion stabilizer
- Caprylic/Capric Triglyceride
- emollient oil
- Vinyl Dimethicone
- skin-conditioning silicone
- Macadamia Integrifolia Seed Oil
- emollient plant oil
- Glyceryl Stearate SE
- emulsifier and emollient
- C12-20 Alkyl Glucoside
- emulsifier
- Nymphaea Alba Flower Extract
- botanical skin conditioner
- Acrylates/C10-30 Alkyl Acrylate Crosspolymer
- gel-forming thickener
- Butyrospermum Parkii Butter / Shea Butter
- occlusive emollient
- C12-16 Alcohols
- fatty alcohol stabilizer
- Tromethamine
- pH-adjusting agent
- Luffa Cylindrica Fruit/Leaf/Stem Extract
- botanical skin conditioner
- Hydrogenated Lecithin
- emollient and emulsifier
- Palmitic Acid
- fatty acid emollient
- Cetyl Palmitate
- texture-enhancing emollient
EXTERNAL CITATIONS
Niacinamide: Topical niacinamide has evidence for barrier support, discoloration, and fine-line improvement.
Ceramide NP: Ceramides are established components of the epidermal barrier and support barrier-focused moisturization.
Adenosine: Topical adenosine has limited but relevant evidence for improving the appearance of wrinkles.
DISCLAIMER: THIS ANALYSIS IS FOR INFORMATION ONLY. NOT MEDICAL ADVICE. AI-GENERATED DATA BASED ON PUBLICLY AVAILABLE INGREDIENT LISTS. VERIFY WITH A MEDICAL PROFESSIONAL.
A cheaper moisturizer with a similar formula
A partial ingredient match (30%), not a close dupe.
SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream: common questions
Is SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream worth it?
SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream scores 3.9 out of 5.0 for efficacy (Effective) and 4.6 out of 5.0 for safety (Very Gentle) on DemythSkin's independent ingredient analysis. A credible peptide moisturizer, not a topical Botox substitute.
What are the key active ingredients in SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream?
SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream contains no gold-standard actives. Its formula is built on supporting and base ingredients rather than clinically transformative actives.
Does SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream contain fragrance or known irritants?
DemythSkin's analysis found no flagged irritants in SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream. It scores 4.6 out of 5.0 for safety.
How is SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Cream scored?
DemythSkin grades every product on two independent scores: efficacy (whether the ingredients have clinical evidence of working) and safety (irritation and sensitisation risk). Ingredients are graded S through D against a database of over 3,000 compounds. Brand and price are not part of the score, and no brand pays for one.
Free scores for every product in the database, or see them on Sephora, Ulta and Amazon with the Chrome extension.