All scans / Eye creams / Skinbetter Science InterFuse Treatment Cream EYE
Skinbetter Science InterFuse Treatment Cream EYE ingredients: is it worth it?
Expensive eye cream with a respectable hydrating base, but its “advanced peptide” positioning oversells modest, concentration-limited results.

Expensive eye cream with a respectable hydrating base, but its “advanced peptide” positioning oversells modest, concentration-limited results.
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The 3.4/5 efficacy score comes primarily from glycerin, niacinamide, emollients, and sodium hyaluronate, with caffeine offering limited appearance-level support for puffiness. The peptide complex and botanical/fermentation ingredients occur after the main base and cannot justify a high score without disclosed concentrations or stronger independent clinical evidence. The 3.4/5 safety score reflects the relatively high placement of Alcohol Denat.; no fragrance is listed.
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DemythSkin rates Skinbetter Science InterFuse Treatment Cream EYE 3.7/5 for efficacy and 4.0/5 for safety.
ACTIVE INGREDIENTS BY TIER
Gold Standards
High clinical proof | Skin-transformativeReliable
Proven resultsPotent
Developing evidenceOverhyped | Marketing
Hype | Limited dataDocumented Irritants
Evidence-backed flagFORMULATION BASE (14)⌄
FULL INGREDIENT LIST⌄
Aqua/Water, Caprylyl Methicone, Glycerin, Jojoba Esters, Niacinamide, PEG-16 Macadamia Glycerides, Cetearyl Alcohol, Glyceryl Stearate, Ceteareth-20, PEG-100 Stearate, Caprylic/Capric Triglyceride, Alcohol Denat., Palmitoyl Tripeptide-38, Caffeine, s-Mu-conotoxin CnIIIC Acetate, Copper Lysinate/Prolinate, Hydrolyzed Lupine Protein, Terminalia Ferdinandiana Fruit Extract, Methylglucoside Phosphate, Sodium Hyaluronate, Saccharomyces Cerevisiae Extract, Arginine, Glycine, Hydroxypropyl Cyclodextrin, Carbomer, Hexylene Glycol, Citric Acid, Sodium Hydroxide, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol.
WHAT EACH INGREDIENT DOES (24)⌄
- Aqua/Water
- Solvent and formula base
- Caprylyl Methicone
- Silicone emollient and slip agent
- Glycerin
- Humectant for water binding
- Jojoba Esters
- Emollient and skin conditioning
- Niacinamide
- Barrier-supporting vitamin B3
- PEG-16 Macadamia Glycerides
- Emollient and emulsifier
- Cetearyl Alcohol
- Fatty alcohol and thickener
- Glyceryl Stearate
- Emollient and emulsifier
- Ceteareth-20
- Emulsifier for oil-water blending
- PEG-100 Stearate
- Emulsifier and texture modifier
- Caprylic/Capric Triglyceride
- Light emollient and skin conditioner
- Alcohol Denat.
- Volatile solvent and texture modifier
- Palmitoyl Tripeptide-38
- Signal peptide for skin conditioning
- Caffeine
- Appearance-supporting decongestant
- s-Mu-conotoxin CnIIIC Acetate
- Neuro-calming peptide ingredient
- Copper Lysinate/Prolinate
- Copper amino-acid complex
- Hydrolyzed Lupine Protein
- Film-forming conditioning protein
- Terminalia Ferdinandiana Fruit Extract
- Botanical antioxidant extract
- Methylglucoside Phosphate
- Humectant and skin conditioner
- Sodium Hyaluronate
- Humectant hyaluronic acid salt
- Saccharomyces Cerevisiae Extract
- Fermentation-derived skin conditioner
- Arginine
- Amino-acid skin conditioner
- Glycine
- Amino-acid skin conditioner
- Hydroxypropyl Cyclodextrin
- Solubilizer and delivery aid
EXTERNAL CITATIONS
Niacinamide: Well-established topical barrier-support and tone-evening ingredient
Glycerin: Well-established topical humectant
Sodium Hyaluronate: Topical humectant supporting temporary skin plumping
Caffeine: Limited topical evidence for temporary improvement in the appearance of puffiness
Palmitoyl Tripeptide-38: Peptide with limited independent clinical evidence compared with established retinoid treatments
DISCLAIMER: THIS ANALYSIS IS FOR INFORMATION ONLY. NOT MEDICAL ADVICE. AI-GENERATED DATA BASED ON PUBLICLY AVAILABLE INGREDIENT LISTS. VERIFY WITH A MEDICAL PROFESSIONAL.
A cheaper eye cream that scores as high or higher
A different formula for the same concern (hydration) that scores at least as high on both efficacy and safety.

Skinbetter Science InterFuse Treatment Cream EYE: common questions
Is Skinbetter Science InterFuse Treatment Cream EYE worth it?
Skinbetter Science InterFuse Treatment Cream EYE scores 3.7 out of 5.0 for efficacy (Modest) and 4.0 out of 5.0 for safety (Gentle) on DemythSkin's independent ingredient analysis. Expensive eye cream with a respectable hydrating base, but its “advanced peptide” positioning oversells modest, concentration-limited results.
What are the key active ingredients in Skinbetter Science InterFuse Treatment Cream EYE?
Skinbetter Science InterFuse Treatment Cream EYE contains no gold-standard actives. Its formula is built on supporting and base ingredients rather than clinically transformative actives.
Does Skinbetter Science InterFuse Treatment Cream EYE contain fragrance or known irritants?
DemythSkin flags these ingredients in Skinbetter Science InterFuse Treatment Cream EYE as documented irritants: Alcohol Denat..
How is Skinbetter Science InterFuse Treatment Cream EYE scored?
DemythSkin grades every product on two independent scores: efficacy (whether the ingredients have clinical evidence of working) and safety (irritation and sensitisation risk). Ingredients are graded S through D against a database of over 3,000 compounds. Brand and price are not part of the score, and no brand pays for one.
Free scores for every product in the database, or see them on Sephora, Ulta and Amazon with the Chrome extension.