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Prequel Multi-Quench Polyglutamic Acid Serum ingredients: is it worth it?
This is a straightforward hydration workhorse serum with no true treatment actives beyond humectants and one nice stress-protection molecule.

This is a straightforward hydration workhorse serum with no true treatment actives beyond humectants and one nice stress-protection molecule.
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The efficacy score is driven by a dense mix of well-established humectants (glycerin, butylene glycol, erythritol, polyglutamic acid) and an evidence-backed compatible solute (ectoin), at a skin-friendly pH around 5.5 that supports barrier comfort but offers no exfoliation, brightening, or anti-aging treatment effect; antioxidants and botanicals are present mainly as supporting players rather than high-impact actives.
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DemythSkin rates Prequel Multi-Quench Polyglutamic Acid Serum 3.6/5 for efficacy and 4.7/5 for safety.
ACTIVE INGREDIENTS BY TIER
Gold Standards
High clinical proof | Skin-transformativeReliable
Proven resultsPotent
Developing evidenceOverhyped | Marketing
Hype | Limited dataDocumented Irritants
Evidence-backed flagFORMULATION BASE (12)⌄
FULL INGREDIENT LIST⌄
Water (Aqua), Glycerin, Butylene Glycol, Polyglutamic Acid, 1,2-Hexanediol, Ectoin, Hibiscus Sabdariffa Fruit Extract, Erythritol, Phenoxyethanol, Propanediol, Xanthan Gum, Caprylyl Glycol, Carbomer, Ethylhexylglycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tocopherol, Citric Acid, Sodium Hydroxide.
WHAT EACH INGREDIENT DOES (18)⌄
- Water (Aqua)
- Primary solvent
- Glycerin
- Humectant for hydration
- Butylene Glycol
- Humectant and penetration aid
- Polyglutamic Acid
- Film-forming humectant
- 1,2-Hexanediol
- Solvent and preservative booster
- Ectoin
- Stress-protection soothing osmolyte
- Hibiscus Sabdariffa Fruit Extract
- Botanical antioxidant and humectant
- Erythritol
- Humectant and moisturizer
- Phenoxyethanol
- Preservative
- Propanediol
- Solvent and humectant
- Xanthan Gum
- Viscosity control and stabilizer
- Caprylyl Glycol
- Emollient and preservative booster
- Carbomer
- Gel thickener
- Ethylhexylglycerin
- Preservative booster and humectant
- Acrylates/C10-30 Alkyl Acrylate Crosspolymer
- Polymer thickener and stabilizer
- Tocopherol
- Antioxidant (vitamin E)
- Citric Acid
- pH adjuster and chelator
- Sodium Hydroxide
- pH adjuster
EXTERNAL CITATIONS
Ectoin: Studies show ectoin functions as a compatible solute that helps protect skin cells from environmental stress and improves barrier resilience when used topically.
Polyglutamic Acid: Experimental data indicate polyglutamic acid can act as a film-forming humectant that enhances skin hydration and supports moisturization when combined with other humectants.
Glycerin: Clinical evidence supports glycerin as a cornerstone humectant that increases stratum corneum hydration and improves skin barrier function in leave-on formulations.
DISCLAIMER: THIS ANALYSIS IS FOR INFORMATION ONLY. NOT MEDICAL ADVICE. AI-GENERATED DATA BASED ON PUBLICLY AVAILABLE INGREDIENT LISTS. VERIFY WITH A MEDICAL PROFESSIONAL.
A cheaper serum that scores as high or higher
A different formula for the same concern (hydration) that scores at least as high on both efficacy and safety.

Prequel Multi-Quench Polyglutamic Acid Serum: common questions
Is Prequel Multi-Quench Polyglutamic Acid Serum worth it?
Prequel Multi-Quench Polyglutamic Acid Serum scores 3.6 out of 5.0 for efficacy (Modest) and 4.7 out of 5.0 for safety (Very Gentle) on DemythSkin's independent ingredient analysis. This is a straightforward hydration workhorse serum with no true treatment actives beyond humectants and one nice stress-protection molecule.
What are the key active ingredients in Prequel Multi-Quench Polyglutamic Acid Serum?
Prequel Multi-Quench Polyglutamic Acid Serum contains no gold-standard actives. Its formula is built on supporting and base ingredients rather than clinically transformative actives.
Does Prequel Multi-Quench Polyglutamic Acid Serum contain fragrance or known irritants?
DemythSkin's analysis found no flagged irritants in Prequel Multi-Quench Polyglutamic Acid Serum. It scores 4.7 out of 5.0 for safety.
How is Prequel Multi-Quench Polyglutamic Acid Serum scored?
DemythSkin grades every product on two independent scores: efficacy (whether the ingredients have clinical evidence of working) and safety (irritation and sensitisation risk). Ingredients are graded S through D against a database of over 3,000 compounds. Brand and price are not part of the score, and no brand pays for one.
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