PanOxyl Adapalene 0.1% Leave-On Gel — Efficacy 4.7/5.0, Safety 4.3/5.0 | DemythSkin
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[ DemythSkin Verdict ]
PanOxyl Adapalene 0.1% Leave-On Gel
PanOxyl

PanOxyl Adapalene 0.1% Leave-On Gel

SerumAcne / Oil Control
Efficacy
Exceptional
4.7 / 5.0
Safety
Safe
4.3 / 5.0
System Verdict
Small formula, serious acne workhorse. The efficacy score is high because adapalene 0.1% is a proven leave-on retinoid at a meaningful strength, and the base is simple enough to support delivery without burying the active; the score is held just below perfect because this is a very minimal gel, so it lacks added barrier support and can still be limited by irritation tolerance rather than formula sophistication.
Active Ingredients Detected
S Tier: Gold StandardsHigh Clinical Proof | Skin-Transformative
Adapalene
B Tier: Supporting IngredientsPromising Ingredients
Edetate DisodiumPoloxamer 182
D Tier: Potential IrritantsBe Cautious
Methylparaben
What Each Ingredient Does
Adapalene
Retinoid acne treatment
Carbomer Homopolymer Type C
Thickener and gel base
Edetate Disodium
Chelator
Methylparaben
Preservative
Poloxamer 182
Emulsifier and solubilizer
Propylene Glycol
Humectant and solvent
Purified Water
Solvent
Sodium Hydroxide
pH adjuster
Full Ingredient List (INCI)

Adapalene USP 0.1%, Carbomer Homopolymer Type C, Edetate Disodium, Methylparaben, Poloxamer 182, Propylene Glycol, Purified Water, Sodium Hydroxide

Frequently Asked

Is PanOxyl Adapalene 0.1% Leave-On Gel worth it?

PanOxyl Adapalene 0.1% Leave-On Gel scores 4.7 out of 5.0 for efficacy (Exceptional) and 4.3 out of 5.0 for safety (Safe) on DemythSkin's independent ingredient analysis. Small formula, serious acne workhorse. The efficacy score is high because adapalene 0.1% is a proven leave-on retinoid at a meaningful strength, and the base is simple enough to support delivery without burying the activ

What are the key active ingredients in PanOxyl Adapalene 0.1% Leave-On Gel?

PanOxyl Adapalene 0.1% Leave-On Gel contains these gold-standard actives with strong clinical evidence: Adapalene.

Does PanOxyl Adapalene 0.1% Leave-On Gel contain fragrance or known irritants?

DemythSkin flags these ingredients in PanOxyl Adapalene 0.1% Leave-On Gel as potential irritants: Methylparaben.

How is PanOxyl Adapalene 0.1% Leave-On Gel scored?

DemythSkin grades every product on two independent axes: efficacy (whether the ingredients have clinical evidence of working) and safety (irritation and sensitisation risk). Ingredients are classified S through D against a database of over 3,000 compounds. No brand pays for a score.

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Analysis last updated: 2026-08-06. DemythSkin is an independent ingredient analyzer. Scores are computed by a deterministic rubric from published clinical evidence — no brand pays for a score. DemythSkin earns commission from affiliate links (Amazon Associates and others). Scores are computed before any commercial relationship — the link follows the verdict, never the other way around.