Kisocare Azelaic Acid Serum 20% — Efficacy 4.4/5.0, Safety 4.4/5.0 | DemythSkin
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[ DemythSkin Verdict ]
Kisocare Azelaic Acid Serum 20%

Kisocare Azelaic Acid Serum 20%

SerumAcne / Oil Control
Efficacy
Strong
4.4 / 5.0
Safety
Safe
4.4 / 5.0
System Verdict
This is a high-strength, clinically-respectable 20% azelaic acid serum in a surprisingly well-buffered, soothing base that is powerful but not foolproof for sensitive skin. Efficacy is strong because 20% azelaic acid is an S Tier active for acne, rosacea-prone redness, and post-inflammatory hyperpigmentation, and here it is high in the INCI with multiple humectants (glycols, hyaluronates) and CICA components (madecassoside, asiaticoside, Centella extract) to support tolerance. However, azelaic acid requires heavy pH adjustment to be workable at 20%, so the formula uses dual bases (sodium hydroxide + tromethamine) and several small acids (gluconolactone, succinic acid, citric acid), meaning the effective pH is likely in a mid range that balances solubility and tolerability but may reduce free-acid bioavailability slightly versus prescription-grade creams, keeping this from S-level performance. The absence of fragrance and drying alcohol supports a relatively high safety score, but the sheer strength of azelaic acid plus added acids means reactive or barrier-impaired skin can still experience stinging, especially if overused or combined with other exfoliants.
Active Ingredients Detected
S Tier: Gold StandardsHigh Clinical Proof | Skin-Transformative
Azelaic Acid
A Tier: Good BasicsProven Results
WaterPanthenolMadecassosideAsiaticosideSuccinic AcidSodium Acetylated HyaluronateSodium HyaluronateHyaluronic Acid Crosspolymer-2-NaHydrolyzed Sodium Hyaluronate
B Tier: Supporting IngredientsPromising Ingredients
Dipropylene GlycolPropanediolSodium HydroxideTromethaminePentylene GlycolPEG-6PEG-32Nicotinamide Adenine DinucleotideGluconolactoneCitric AcidCentella Asiatica ExtractButylene GlycolPhenoxyethanolHydroxyethylcellulose
D Tier: Potential IrritantsBe Cautious
Ethylhexylglycerin
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DemythSkin is an independent ingredient analyzer. Scores are computed by a deterministic rubric from published clinical evidence — no brand pays for a score.