Avène Cleanance Acne Medicated Clearing Gel Cleanser — Efficacy 4.2/5.0, Safety 4.8/5.0 | DemythSkin
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[ DemythSkin Verdict ]
Avène Cleanance Acne Medicated Clearing Gel Cleanser

Avène Cleanance Acne Medicated Clearing Gel Cleanser

CleanserAcne / Oil Control
Efficacy
Strong
4.2 / 5.0
Safety
Excellent
4.8 / 5.0
System Verdict
This is a clinically competent salicylic acid acne cleanser with a surprisingly gentle surfactant base—but it’s still a medicated treatment, not a fluffy sensitive-skin wash. Efficacy-wise, it earns its score because 2% salicylic acid (S Tier for acne) is at the legally required treatment level in a cleanser format and paired with an appropriate pH-buffering system, so you will get meaningful comedolytic and anti-inflammatory benefit on contact, even though it is rinse-off. The base uses milder surfactants like sodium cocoyl isethionate, coco-glucoside and cocamidopropyl hydroxysultaine (A/B Tier for barrier-friendliness) instead of harsh SLS, with humectants such as glycerin, betaine and saccharide isomerate to reduce stripping. I am not pushing the score higher because this is still an acid cleanser: you must keep it on the skin briefly to get effect, and any postbiotic/probiotic marketing (lactobacillus ferment lysate, C/D Tier in rinse-off) is essentially cosmetic in this context.
Active Ingredients Detected
S Tier: Gold StandardsHigh Clinical Proof | Skin-Transformative
Salicylic Acid
A Tier: Good BasicsProven Results
Water (Aqua)BetaineGlycerinLactobacillus Ferment Lysate
B Tier: Supporting IngredientsPromising Ingredients
Sodium Cocoyl IsethionateCocamidopropyl HydroxysultainePropanediolStearyl AlcoholCoco-GlucosideSodium Lauroyl SarcosinateGlyceryl LaurateSodium ChlorideCetearyl OlivateHydroxypropyl MethylcelluloseSodium BenzoateSaccharide IsomerateSorbitan OlivateHydroxypropyl Guar Hydroxypropyltrimonium ChlorideXanthan GumTrisodium Ethylenediamine DisuccinatePotassium SorbateCitric AcidSodium CitrateAcrylates Copolymer
Analyze on DemythSkin

DemythSkin is an independent ingredient analyzer. Scores are computed by a deterministic rubric from published clinical evidence — no brand pays for a score.